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BIOMEDICAL RESEARCH UNIT

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Aims

Investigate the function of the steroid hormones and their transport proteins, and their role in spermatogenesis and in proliferative diseases.These mechanisms are studied in prostate, endometrial, pancreatic and ovary tumors, neuroblastoma, and prostatic benign hyperplasia. Another research topic analyses the role of matrix proteins in wound healing.

Staff


Head of Biomedical Research Unit:
Jaume Reventós Puigjaner
Lab Phone: 93 489 4052
jreventos@ir.vhebron.net



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Researchers
Francina Munell Casadesus
Rosanna Paciucci
María Teresa Quiles Pérez
Mª Antonia Arbós Vila
Miguel Abal Posada
Jordi Pétriz González
Josep Roma Castanyer
Soledad Gallego Melcom
Joan Morote Robles
Enric Trilla Herrera
Lluis Cechini
Jordi Xercavins Montosa
Antonio Gil Moreno
Andreas Doll
 
Technical Personnel
Cristina Oliva Rodriguez
Marta González Martínez
Ana Romero Morilla

 

PhD Students
Mariano Hurtado Martínez
Toni Hurtado Rodríguez
Tomás Pinós Figueras
Marta Monge Azemar
Albert Santamaría Martínez
Ariadna Abedaño Pons
Lide Alaña Rodrigo
Esther Castillo Andreo
Valentí Gómez Martínez
Ramón Díaz Peña
Antonia Fraga Salord
Hafid Alazzouzi
Jordi Guillen Martí
Eva Colàs Ortega
Anna Barbosa Desongles

Research Areas



“Characterization of transcriptional patterns in prostate benign hyperplasia development in dog”
“Molecular markers identification for diagnosis and prognosis of endometrial cancer”

Principal investigator: Jaume Reventós Puigjaner.

“Transporter protein for sexual hormones (SHBG): regulation, localization and action of the two SHBG alternative transcription units”
“Estrogen beta receptor (ERβ): Differential expression and specific actions along the cell cycle. Molecular mechanisms involved in the negative proliferation control”
“Reproduction: SHBG and ERβ actions in spermatogenesis progression and in male infertility”.
“Prostate cancer: SHGB and ERβ in prostate cancer. Cancer stem cells involvement in the development of the immunoresistance”

Principal investigator: Francina Munell Casadesus.rbiomedica_fig.jpg

“Molecular mechanisms in prostate cancer. Characterization of a newly identified protein PTOV1 overexpressed in cancer and in prostate intraepithelial neoplasia (PIN)”
“Characterization of PTOV1 protein role and the importance of its flotilin-1 interaction in proliferation control and tumor progression using in vitro and in animal models”
“Molecular mechanisms involved in pancreas cancer: role for the plasminogen tissue activator (tPA) and the annexin II receptor in proliferation and tumor progression. tPA signal transduction in the induction of proliferation”
“Development and evaluation for selective uPA and tPA protease inhibitors with potential application in antitumoral therapy”
Principal investigator: Rosanna Paciucci.

“Identification and characterization of genetic, fenotypic and functional patterns with diagnostic and prognostic value involved in the genesis of the incisional hernia in connective and muscle tissues. Mechanosignaling”
Principal investigator: Mª Antonia Arbós Vila.

“Epithelial-mesenchymal interaction. Involvement in tumor progresión”
Principal investigator: Maria Teresa Quiles Pérez.

“Characterization of the ErbB2 receptor in metastasis and angiogenesis processes in prostate cancer. Development of inducible cellular and animal models to design new experimental therapies”
Principal investigator: Miguel Abal Posada

“Side effects in androgenic suppression”
“Analysis of the osteoporosis induced by androgenic suppression”.
 “Significance of the saturation needle biopsy in prostate cancer diagnosis”

Principal investigator: Joan Morote Robles.

“Research on the minimal residual disease (MRD) in the most frecuent pediatric solid  neoplasias: neuroblastomas, soft tissue sarcoma and Ewing sarcoma”
“Molecular classification of soft tissue sarcomas by genetic alteration analysis and by cDNA microarray for gene expression”
“Characterization of the expression pattern for the new tyrosine hydroxylase isoforms present in neuroblastoma”

Principal investigator: Soledad Gallego Melcom.

“Análisis of the centinel gangion in inicial cervix cancer”
Principal investigator: Antonio Gil Moreno.


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Contact us: institutrecerca@ir.vhebron.net, tel: +34 93 489 4337,  fax: +34 93 489 4102

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