Aims

Solid tumors in Pediatrics: Working in cancer molecular biology, we are mainly focused in the molecular features of neuroblastoma and sarcomas in pediatric patients. By analyzing specific gene expression with real time PCR techniques, we are currently studying the prognostic value of the sarcoma residual disease. We have also initiated gene expression analysis in rabdomyosarcome samples by high throughput cDNA microarrays.

- Blood diseases and hematopoietic stem cell transplantation: study of epidemiologic, clinic, and genetic factors relevants in malignant (leukaemia) and non malignant (Fanconi anemia) homeodiseases. Study of umbilical cord blood transplant: recommendations, implant, hematologic and immunologic reconstitution and procedure related complications. Development of protocols for the prevention diagnosis and treatment for infections in transplanted patients.

-Transfusional medicine and immunohematology: ex vivo expansion of bone marrow for tissue regeneration. Use of  AC133 progenitors from peripheral blood for myocardial regeneration.

Head of Transfusion Medicine and Pediatric Hematoncologic Diseases Research Group: José Sánchez de Toledo Codina
Tel. 93 489 3089
jossanch@vhebron.net

Researchers   Gema Acebedo Lerzundy Pilar Bastida Vila Ma. Dolores Castellà Cahiz Cristina Díaz de Heredia Rubio Soledad Gallego Melcom Joan García López Luís Gros Subias José Manuel Hernández Sánchez Ana Llort Sales Pedro Madoz Reano Gregorio Martín Henao Marta Martorell Murtra Lluís Massuet Bosch Núria Nogués Gálvez

Laura Ocaña Safont Juan José Ortega Aramburu Teresa Olivé Oliveras Eduard Palou Rivera Sergi Querol Giner Josep Roma Castanyer Luciano Rodríguez Gómez Constantino Sábado Álvarez Esther Saus Martínez Laia Subirana Soriano Mónica Tejeda Lorenzo Marta Torrabadella Reynoso

“Pediatric malignant tumors”
Principal investigator: Soledad Gallego Melcom.
Research on the minimal residual disease in the most frecuent pediatric solid neoplasias: neuroblastomas, soft tissue sarcoma and Ewing sarcoma.Molecular classification of soft tissue sarcomas by genetic alteration analysis and by cDNA microarray for gene expression.Characterization of the expression pattern for the new tyrosine hydroxylase isoforms in neuroblastoma and its putative application to study the minimal residual disease.

“Blood diseases and progenitor transplant”
Principal investigator: Juan José Ortega Aramburu.
Epidemiology of acute and chronic leukemia during childhood.
Clinical and genetic manifestations and therapeutic approaches for Fanconi anemia. Prevention, diagnostic and treatment of the bacterial, viral and fungi infections in haematopoietic progenitor transplant. Umbilical cord blood transplant procedure:  indications (recommendations, implant prognostic factors, haematological and immunologic reconstitution and complications.

“Transfusion medicine and immunohaematology”
Principal investigator: Pedro Madoz Reano.
Ex vivo expansion of bone marrow for tissue regeneration.
Use of  AC133 progenitors from peripheral blood for myocardial regeneration.