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GROWTH FACTORS AND CANCER RESEARCH GROUP

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Aims

Analyze the role of specific signal transduction pathways in cancer development. We are trying to characterize the intracellular transit of ADAM17/TACE, a metalloprotease required for epidermal growth factor receptor (EGFR) activation. We are also studying the involvement of this receptor in tumor development, and the effect of different drugs that inhibit its kinase activity.

Staff



Head of Growth Factors and Cancer Research Group:
Joaquín Arribas López
Tel. 93 274 6026
jarribas@ir.vhebron.net



fcreixement_grup.jpgResearches
Belén Santiago Josefat
Kim Pedersen
Cary Esselens

PhD Students
Joan Josep Bech Serra
Judit Anido Folgueira
Soraya Ruiz Paz
Maria Teresa Villanueva de la Torre
Manel García Medina
Jesús García Castillo
Pier Davide Angellini
  




 

Research Areas




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“EGFR-like receptors as therapeutic targets”
Principal investigator: Joaquín Arribas López (in collaboration with Josep Baselga Torres group).
We would like to emphasize the analysis of the role of certain metalloproteases in growth factor activation that at the same time activate the epidermal growth factor receptor (EGFR). Furthermore, we are investigating the effect of monoclonal antibodies against EGF receptor or directly against its kinase domain in preclinical models.



 

“Proteolysis at the cellular surface and extracellular matrix remodelling”
Principal investigator: Joaquín Arribas López.
One of the more challenging tasks in this field is defining the different susbstrates for a specific metalloprotease. The best approach to achieve this objective is by using proteomic techniques that allow comparison between genetically deficient cells for a specific metalloprotease and control cells. Recent implementation of the proteomic service in our program will facilitate us to complete this task.

 

“Biosynthesis and regulation of C-terminal fragments from the HER2 proto-oncogen”
Principal investigator: Joaquín Arribas López.
The mechanisms for the HER2 (CTFs) C-terminal fragments synthesis have been recently undercover. These data will allow us to investigate the following aims:

- CTFs characterization (subcellular localization, kinase activity, etc.).
- Generation of transgenic mice expressing CTFs.
- Comparative analysis of the CTFs overexpressing cells transcriptome vs. control cells transcriptome.

 

 


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Institut Recerca Hospital Universitari Vall d’Hebron. 2008      
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Contact us: institutrecerca@ir.vhebron.net, tel: +34 93 489 4337,  fax: +34 93 489 4102

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