“Characterization of novel acting mechanisms of the Hepatocyte Growth Factor (HGF) in melanomagenesis: Bring into play the UV induced HGF transgenic animal model”.
Coordinator: Juan A. Recio Conde.
Applying proteomic technology and and biochemical and genetic approaches we willl try to get new insights about the mechanisms involved in melanoma development and progresion.
“Preclinical study in melanoma development using specific PI3K and BRaf inhibitors.”.
Coordinator: Juan A. Recio Conde.
Investigations reveal that Ras and PI3K pathways appear to be important players in melanoma development. We are using specific inbitors against molecules to target this two pathways to test their therapeutic relevance in the mouse melanoma model.
“Protein methylation as a modulator of cell signaling induced by growth factors and stress.”.
Coordinator: Juan A. Recio Conde.
Protein methylation is emerging as an important postranslational modification.We will sudy the cooperation between protein phosphorylation and protein mehylation in cell signaling mediated by growth factors and stress .