“Escherichia coli. Extraintestinal infection, poblational dynamics and virulence factors..”
Coordinators: Guillem Prats Pastor and Antònia Andreu Domingo
Study of the phylogenetic groups, virulent factors and pathogenicity islands (PAIs) of E. coli causing extraintestinal infections. Study of the fecal populations of E. coli in healthy women and in women with urinary tract infection. Identifications of new virulence factors by directed mutagenesis using IVET. Animal models of subcutaneous infection and urinary tract infections in rats
“Neonatal early-onset sepsis. Pathogenicity, epidemiology, vertical transmission and antimicrobial resistance.”
Coordinators: Antònia Andreu and Gemma Codina Epidemiology and profilaxy of the early sepsis: E. coli, GBS, L. monocytogenes. Detection of hipervirulent clons. Molecular techniques for the diagnostic of early sepsis and meningitis of vertical transmition. Characterization of the genetic mechanisms that confer GBS resistance to macrolides, lincosamines and ketolides.
“Characterization of the molecular mechanisms that confer antimicrobial resistance. Clinical implications. Surveillance and control of nosocomial infection”
Coordinators: Guillem Prats and Montserrat Sabaté
Resistances to quinolones and fluoroquinolones mediated by plasmid genes. Origin and diffusion of the enterobacteria resistant to cephalosporins and carbapenems isolated from different environments. AmpC sequence as a tool for identification of enterobacteria carrying chromosomal beta-lactamases. Continuous monitoring of multi-resistant bacteria in the neonatal Intensive Care Unit.
“Evaluation of new diagnostic technologies. Molecular diagnostic. ”
Coordinator: Gema Codina
Evaluation of PCR, real-time PCR, hibridation and sequencing for the detection of different pathogens including the causal agents of fungic invasive infection and the agents of neonatal early-onset sepsis and meningitis of vertical transmission. Design and evaluation of molecular techniques for epidemiology studies: PFGE and ERIC.
“Immunological and lesional mechanisms in late adverse reactions of bioimplants.”
Coordinator: Jaume Alijotas Reig
The late clinical manifestations that occur when bioimplants are placed seem to have an immune component. We study the histological characteristics of the most frequently used implants and the lesional mechanisms. We analyze the role that bacteria may have on the induction and/or maintenance of such reactions and the correlation that may exist between some HLA haplotypes and the adverse reactions.
“Micobacteria. Tuberculostatics resistance ”
Coordinator: Núria Martín Casabona
Standardization procedures for the study of M. tuberculosis and M. avium antimicrobial susceptibility. Participation on the WHO and IUATLD international network. Acting as a “WHO Supranacional Reference Laboratory” for the M. tuberculosis antimicrobial susceptibility quality control. Standardization of M.tuberculosis susceptibility tests to second line drugs.