“Programmed Cell Death and Parkinson´s disease ”
Coordinator: Miquel Vila
Study the molecular mechanisms that regulate the process of programmed cell death in dopaminergic neurons using an animal model of Parkinson´s disease. Our goal is to identify molecular targets and design new molecular tools which may allow us, acting on this process. to prevent or delay the neurodegeneration that occurs in Parkinson's disease.
“Role of mitochondrial dysfunction in Parkinson's disease neurodegeneration”
Coordinator: Miquel Vila
To characterize the role and the molecular mechanisms of mitochondrial dysfunction occurring in Parkinson’s disease’s.
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“Mechanisms and significance of Lewy body formation in Parkinson’s disease”Coordinator: Miquel Vila
In addition to dopaminergic neuron cell death, Parkinson’s disease is chatacterized, from a neuropathological point of view, by the presence of intraneuronal proteinacious cytoplasmic inclusions, called Lewy bodies, in affected neurons. The mechanisms and significance of Lewy body formation in Parkinson’s disease is unknown. Here, we will determine the potential involvement of the autophagy-lysosomal degradation system in the formation of Lewy bodies.