”Neurotraumatology and neurocritical patient monitoring ”
Coordinators: J. Sahuquillo, A. Garnacho
Aims: 1) To expand on the knowledge of metabolic and O2 transport alterations at tissue level in acute brain lesions; 2) To study cerebral and systemic neuroinflammatory response through high resolution microdialysis techniques; and 3) To analyse peri-infarct depolarisation phenomena in patients suffering from acute brain injury (COSBID european study).
“Hydrocephalus and CSF dynamics alterations “
Coordinators: M. A. Poca, J. Sahuquillo .
Aims: 1) To expand on the physiopathology of normal pressure hydrocephalus and idiopathic intracraneal hypertension; 2) To improve cognitive function in adolescent and adult patients with Spina Bifida and apparently 'arrested' hydrocephalus sequelae; and 3) To increase our biobank with CSF and blood samples from patients with these pathologies (over 200 at present).
“Malignant Infarction of the Middle Cerebral Artery (MMCAI) ”
Coordinators: J. Sahuquillo, J. Alvarez Sabín
Aims: To expand on the physiopathology, metabolic alterations, and monitoring of patients with malignant MCA infarction. To optimise treatment through the use of novel techniques such as moderate hypothermia and decompressive craniectomy. Projects within this line of research also include characterising the inflammatory response profile (cerebral and systemic) triggered by massive ischemic stroke.
“Chiari and craniocervical junction malformations ”
Coordinators: M. A. Poca, J. Sahuquillo .
Aims: To improve knowledge of physiopathology of craniocervical malformations, particularly of Chiari type I (MC-I), and quantify its clinical, social and work repercussions. We also aim to either establish or discard an association of MC-I with chronic fatigue syndrome and fibromyalgia, as well as define familiar repercussions and genetic bases of this malformation.
“Neurovascular hemorrhagic pathology "
Coordinators: Dr. J. Vilalta, F. Romero .
Aims: To develop a registry, centralised in external servers, for the study of both epidemiological and etiologic factors, and results of treatment in cerebral aneurysms and spontaneous cerebral hematomas. To analyse the effects of surgical maneuvers on brain tissue oxygen pressure and evoked potentials, in order to improve safety during surgical procedures.