“Searching for diagnostic and prognostic biomarkers in stroke “
Coordinator: Anna Rosell Novel and Joan Montaner Villalonga.
Study of endogenous fibrinolysis, apoptosis and angiogenesis markers in cerebral ischaemia. Mechanisms of haemorraghic transformation in ischaemia mediated by matrix metalloproteinases. Molecular mechanisms of MMP-9 activation by t-PA (i.e LRP). Identification of markers to get an analytical stroke diagnostic.
“New imaging technics for cerebrovascular pathology ”
Coordinator: Carlos Molina Cateriano and Marc Ribó Jacobi
Diffusion-perfusion techniques for the selection of patients with non-hemorraghic stroke in the hyperacute phase for fibrinolytic treatment. Fibrinolysis potentiation by ultrasounds in the clinical side (Clotbust III) and experimental (sonothrombolysis model in rats). Microbubbles. PFO.
“Caracterització de mecanismes d’acció de fàrmacs neuroprotectors”
Coordinator: José Alvarez-Sabín and Joan Montaner Villalonga
Study of the neuroprotective effect of those drugs used experimentally in the acute phase of ischaemic stroke (statins: MISTIC trial). Control and modification of glucemia state in response to reperfusion treatments
“Pharmacogenetics studies in cerebrovascular pathology “
Coordinator: Israel Fernández Cadenas and Joan Montaner Villalonga
Study of genetic polymorphisms that modify the response to thrombolytic treatment (Geno-tPA).
“Analysis of genes and proteins of different cellular populations in human cerebral tissue from patients suffering from stroke “
Coordinator: Anna Rosell Novel and Eloy Cuadrado Godia
Analyze the components of the neurovascular unit (endothelium, glia, neuron) in the different areas of the infarct and in the perifery by laser-capture-microdissection.
Other research areas :
“Neuroinflammatory mechanisms in malignant middle cerebral artery infarction" (Pilar Delgado Martínez)
"Risk haplotypes in Cerebral Amyloid Angiopathy” (Pilar Delgado Martínez)